Pantothenic acid (vitamin B-5) was discovered by a pioneer in nutrition Roger Williams in 1919. Being essential to all forms of life Pantothenic acid is found throughout living cells in the form of coenzyme A (CoA), a vital coenzyme in numerous cellular chemical reactions. One important function is to assist turning carbohydrates and fats into usable energy. As its use in the body is so widespread, a short fall of Ca Pantothenate can affect nearly all biochemical functions.
Small quantities of pantothenic acid are found in most foods. The major food source of pantothenic acid is in meats, although the concentration found in animal muscle tissue is only about half the amount that is found in human muscle tissue. Milling often removes much of the pantothenic acid from whole grains. Broccoli, cauliflower, asparagus, avocados, crimini and shiitake mushrooms provide an excellent food source. The most significant food source though is cold water fish ovaries and royal jelly.
Benefits and how it works:
Pantothenic acid, a B-vitamin, is essential for normal physiological functions. It is a precursor of coenzyme A (CoA) and acyl, a carrier protein of fatty acid synthase, which are involved in more than 100 different metabolic pathways including energy metabolism of carbohydrates, proteins and lipids, and the synthesis of lipids, neurotransmitters, steroid hormones, porphyrins and haemoglobin.
Clinical improvements of osteoarthritis have been reported with 12mg pantothenic acid daily as pantothenic acid is involved in cartilage growth.
Various nutrients are useful in supporting and enhancing adrenal function, particularly during times of stress. Atrophy or shrinking of the adrenal cortex is a common side effect of continual stress, cortisone administration and gaining. Due to the importance of the adrenal gland, optimum health is dependent on optimum adrenal function. Vit C, Vit B-6, zinc magnesium and pantothenic acid are necessary nutrients for the manufacture of hormones by the adrenal glands. Supplementation of all these nutrients at higher than RDA levels may be appropriate during high periods of stress or when adrenal support is needed. Pantothenic acid is particularly important for optimum adrenal functioning as a deficiency results in adrenal atrophy, characterised by fatigue, headache, sleep disturbances, nausea and abdominal discomfort. Food sources are insufficient in times of acute or chronic stress conditions.
Pantothenic acid is used in the synthesis of coenzyme A (CoA), an essential coenzyme in a variety of reactions that sustain life. CoA is required for chemical reactions that generate energy from food (fat, carbohydrates, and proteins). The synthesis of essential fats, cholesterol, and steroid hormones requires CoA, as does the synthesis of the neurotransmitter, acetylcholine, and the hormone, melatonin. Haem, a component of haemoglobin, requires a CoA-containing compound for its synthesis. Metabolism of a number of drugs and toxins by the liver requires CoA (3).
Coenzyme A may act as an acyl group carrier to form acetyl-CoA and other related compounds; this is a way to transport carbon atoms within the cell. CoA is important in energy metabolism for pyruvate to enter the tricarboxylic acid cycle (TCA cycle) as acetyl-CoA, and for α-ketoglutarate to be transformed to succinyl-CoA in the cycle. CoA is also important in the biosynthesis of many important compounds such as fatty acids, cholesterol, and acetylcholine
A deficiency produces impaired energy production, due to low CoA levels, which could cause symptoms of irritability, fatigue, and apathy. Acetylcholine synthesis is also impaired, producing neurological symptoms including numbness, paraesthesia, and muscle cramps.
A deficiency in pantothenic acid can also cause hypoglycaemia, or an increased sensitivity to insulin. Insulin receptors are acylated with palmitic acid when they do not want to bind with insulin. Therefore, more insulin will bind to receptors when acylation decreases, causing hypoglycaemia.
1-2 caps daily. This can be repeated 2-3 times per day or as required. No reported side effects known.
|Product||No of Caps||Each cap contains|
|Ca Pantothenate||60||Calcium pantothenate||300mg|